The state's high court said Friday it would deny an appeal by the actress in her wrongful termination case against ABC and Touchstone Television.
Sheridan said she was fired because she claimed she was hit in the head by series creator Marc Cherry. ABC attorneys claimed Sheridan's contract simply was not renewed.
In March jurors deadlocked after a two-week trial. An appeals court found in August that Sheridan was not entitled to a new trial, but should be allowed to file an amended lawsuit claiming she was retaliated against because she complained about her boss.
"Desperate Housewives" concluded its eight-season run this year.
Calls to Sheridan's representatives were not immediately returned Sunday.