A publicist for Depp said in a statement Tuesday that the two "have amicably separated." The statement requested privacy for the former couple and their two children, 9-year-old son, Jack, and 13-year-old daughter, Lily-Rose.
Depp and Paradis met in 1998 but never married during their 14-year relationship. The American actor and the French model-singer lived together with their children in France.
Depp's most recent film credits include "The Rum Diary" and "Dark Shadows." He is set to star as Tonto in the big-screen take on "The Lone Ranger," due next year.