The academy's Hall of Fame selection committee announced the list of inductees for 2014 on Monday.
Louis-Dreyfus is a four-time Emmy Award winner and Leno is known as the host of the "Tonight Show." They'll be joined by media magnate Rupert Murdoch, writer-producer David E. Kelley and network executive Brandon Stoddard.
Sound pioneer Ray Dolby will be inducted posthumously.
The new Hall of Fame members will be honored at a Beverly Hills ceremony in March.
Past honorees include Lucille Ball, Walt Disney, Bob Hope and Bill Cosby.