Trump fires back at Paul Ryan: 'not ready to support' Speaker's agenda

House Speaker Paul Ryan of Wis. finishes a news conference at the Republican National Committee on Capitol Hill in Washington, Tuesday, April 12, 2016, after insisting that he will not be a candidate in the Republican presidential race. The statement comes after weeks of speculation that Ryan could emerge as the GOP nominee if there's a contested Republican convention. (AP Photo/J. Scott Applewhite)

House Speaker Paul Ryan Thursday told CNN he "cannot support Donald Trump right now."

Ryan is the GOP's highest-ranking office holder and made the stunning announcement on CNN's "The Lead" on Thursday.

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Trump is presumptive nominee for the GOP's bid for the presidency after Sen. Ted Cruz and Ohio Gov. John Kasich failed to mark their mark at the Indiana primary. But Ryan told CNN's Jake Tapper that the billionaire businessman had work to do unite the party.

"I want to be a part of helping him do that but I think there is some work to do here," Ryan said. "We need a standard bearer who can unite all wings of our party."

"I think it's possible. But we're not there right now," Ryan continued.

Trump later fired back, saying he's "not ready to support" Ryan's agenda.

In a statement released by his campaign, Trump says, "Perhaps in the future we can work together and come to an agreement about what is best for the American people."

Trump says Americans have been "been treated so badly for so long that it is about time for politicians to put them first!"

The statement from the popular Ryan is further evidence of how much resistance remains inside the party to Trump's candidacy.

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A "Never Trump" movement gained momentum after Tuesday's primary, giving rise to a trend online "#RepublicansForHillary."

"No Republican should ever think about supporting Hillary Clinton," Ryan said flatly.

Trump has been criticized for views that conflict with typical conservative ideals: he's open to a minimum wage increase, he has oppositions to free trade and he has flip-flopped his views on abortion.

Ryan concluded his interview with Tapper by once again denying he would consider a bid for the presidency himself.

The Associated Press contributed to this report.

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